Michael D Smith Selected Research

tanezumab

1/2018	Safety and efficacy of subcutaneous tanezumab in patients with knee or hip osteoarthritis.
4/2016	Tanezumab Reduces Pain in Women with Interstitial Cystitis/Bladder Pain Syndrome and Patients with Nonurological Associated Somatic Syndromes.
2/2016	When Is Osteonecrosis Not Osteonecrosis?: Adjudication of Reported Serious Adverse Joint Events in the Tanezumab Clinical Development Program.
9/2015	Efficacy and safety of tanezumab in the treatment of pain from bone metastases.
6/2015	Efficacy and safety of tanezumab monotherapy or combined with non-steroidal anti-inflammatory drugs in the treatment of knee or hip osteoarthritis pain.
11/2014	A phase III placebo- and oxycodone-controlled study of tanezumab in adults with osteoarthritis pain of the hip or knee: response.
11/2014	Efficacy and safety of intravenous tanezumab for the symptomatic treatment of osteoarthritis: 2 randomized controlled trials versus naproxen.
10/2014	Nerve safety of tanezumab, a nerve growth factor inhibitor for pain treatment.
9/2014	Efficacy and safety of tanezumab added on to diclofenac sustained release in patients with knee or hip osteoarthritis: a double-blind, placebo-controlled, parallel-group, multicentre phase III randomised clinical trial.
7/2013	Tanezumab reduces osteoarthritic hip pain: results of a randomized, double-blind, placebo-controlled phase III trial.

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Michael D Smith Research Topics

Disease

13	Pain (Aches) 01/2018 - 07/2012
9	Osteoarthritis 01/2018 - 08/2012
7	Neoplasms (Cancer) 01/2022 - 03/2011
5	Chronic Pain 02/2016 - 01/2013
4	Pneumonia (Pneumonitis) 01/2021 - 07/2003
4	Hip Osteoarthritis (Coxarthrosis) 01/2018 - 09/2014
4	Pneumococcal Infections 01/2011 - 07/2003
2	Morphine Dependence 09/2017 - 01/2017
2	Low Back Pain (Lumbago) 02/2016 - 03/2015
2	Bacteremia 04/2009 - 07/2003
1	Hereditary Angioedemas 01/2022
1	Glioblastoma (Glioblastoma Multiforme) 01/2022
1	Confusion (Bewilderment) 10/2021
1	Colorectal Neoplasms (Colorectal Cancer) 10/2020
1	Congenital Heart Defects (Congenital Heart Defect) 12/2019
1	Down Syndrome (Down's Syndrome) 12/2019
1	Heart Diseases (Heart Disease) 12/2019
1	ST Elevation Myocardial Infarction 11/2017
1	Pelvic Pain 04/2016
1	Prostatitis 04/2016
1	Interstitial Cystitis (Interstitial Cystitis, Chronic) 04/2016
1	Osteonecrosis (Kienbock's Disease) 02/2016
1	Stress Fractures (Stress Fracture) 02/2016
1	Cancer Pain 02/2016
1	Neoplasm Metastasis (Metastasis) 09/2015
1	Sleep Apnea Syndromes (Sleep Apnea) 03/2015
1	Paresthesia (Dysesthesia) 11/2014
1	Edema (Dropsy) 11/2014
1	Hyperesthesia 11/2014
1	Arthralgia (Joint Pain) 11/2014
1	Hypesthesia (Numbness) 11/2014
1	Knee Osteoarthritis 09/2014
1	Wounds and Injuries (Trauma) 07/2012
1	Asthenia 04/2012
1	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 04/2012
1	Dizziness (Lightheadedness) 04/2012
1	Nausea 04/2012
1	Headache (Headaches) 04/2012
1	Sleep Initiation and Maintenance Disorders (Insomnia) 04/2012
1	Infections 07/2003
1	Spondylolisthesis 06/2003
1	Delirium 05/2003
1	Cognitive Dysfunction 05/2003

Drug/Important Bio-Agent (IBA)

12	tanezumabIBA 01/2018 - 08/2012
4	AntigensIBA 01/2021 - 07/2003
4	Monoclonal AntibodiesIBA 11/2018 - 09/2014
4	Prostaglandins AIBA 01/2018 - 08/2012
4	Morphine (MS Contin)FDA LinkGeneric 09/2017 - 07/2012
4	Nerve Growth Factor (NGF)IBA 02/2016 - 09/2014
3	Opioid Analgesics (Opioids)IBA 09/2015 - 01/2015
2	Pharmaceutical PreparationsIBA 10/2021 - 11/2018
2	Immunoconjugates (Immunoconjugate)IBA 01/2021 - 11/2018
2	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 11/2020
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 07/2003
2	Proteins (Proteins, Gene)FDA Link 11/2018 - 03/2011
2	TabletsIBA 09/2017 - 01/2017
2	Oxycodone (Oxycontin)FDA LinkGeneric 11/2014 - 01/2013
2	Polysaccharides (Glycans)IBA 01/2011 - 10/2005
1	Hormones (Hormone)IBA 01/2022
1	Plasma KallikreinIBA 01/2022
1	sebetralstatIBA 01/2022
1	O-GlcNAc transferaseIBA 01/2022
1	BradykininIBA 01/2022
1	Acetyl Coenzyme A (Acetyl-CoA)IBA 01/2022
1	Acetates (Acetic Acid Esters)FDA Link 01/2022
1	High-Molecular-Weight Kininogen (Kininogen, High Molecular Weight)IBA 01/2022
1	Ethanol (Ethyl Alcohol)IBA 10/2021
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	Cathepsin BIBA 11/2020
1	aniline (aniline hydrobromide)IBA 11/2020
1	auristatinIBA 10/2020
1	indusatumabIBA 10/2020
1	Membrane Proteins (Integral Membrane Proteins)IBA 11/2018
1	Immunoglobulin G (IgG)IBA 11/2018
1	Enterotoxin ReceptorsIBA 11/2018
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 06/2015
1	Hydromorphone (Dilaudid)FDA LinkGeneric 03/2015
1	Naloxone (Narcan)FDA LinkGeneric 01/2015
1	Naproxen (Naprosyn)FDA LinkGeneric 11/2014
1	Diclofenac (SR 38)FDA LinkGeneric 09/2014
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2013
1	Analgesics (Analgesic Drugs)IBA 08/2012
1	Fentanyl (Sublimaze)FDA LinkGeneric 07/2012
1	Buspirone (Buspar)FDA LinkGeneric 04/2012
1	Atomoxetine Hydrochloride (Strattera)FDA LinkGeneric 04/2012
1	EnzymesIBA 03/2011
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 03/2011
1	Conjugate VaccinesIBA 01/2011
1	VaccinesIBA 10/2005
1	cyclo(Arg-Pro) (CI 4)IBA 05/2003

Therapy/Procedure

4	Therapeutics 01/2021 - 03/2015
2	Analgesia 09/2015 - 03/2015
1	Intravenous Administration 10/2020
1	Enteral Nutrition (Feeding, Tube) 12/2019
1	Gastrostomy 12/2019
1	Arthrodesis 06/2003